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Molcode has developed special QSAR ServiceTM for REACH legislation and provides fullydocumented REACH compliant Data based on experimental laboratory tests performed according to OECD Guidlines.

Molcode has introduced a three-step approach to proceed from request to REACH QSAR Reports:

Step 1 is free of charge for the customer, and provides information of the overall availability of QSAR endpoints for the particular substance based on an initial applicability domain (AD) evaluation. Sample report.

Step 2 (optional) provides substance based information with preliminary predictions for all available endpoints and/or scale/category estimations. It is intended to provide the customer with feedback of what the predictions will be like, and information to base their further strategy on. A fee of 100 EUR per substance applies. Sample report.

Step 3. Preparation of final substance and endpoint specific QSAR REACH compliant reports (QPRF). It includes fully documented prediction, category evaluation (where applicable), literature search and read-across. A FEE applies according to the price list for the selected endpoint. Sample QPRF.

For more information please contact Dr. Eneli Hark

 

List of available endpoints


REACH OECD Endpoint QSAR
Annex VII
7.7 105 Water Solubility 1.3
7.8 107 Partition Coefficient n-octanol/water 1.6
8.3 429 Skin Sensitisation 4.6
8.3 406 Skin Sensitisation 4.6
8.4.1 471 In vitro Gene Mutation study in Bacteria 4.10
8.5.1 423 Acute Toxicity -  Oral 4.2
9.1.1 202 Acute toxicity for Daphnia Magna 3.1
9.1.2 201 Growth Inhibition study on algae 3.2
9.2.1.1 301 Persistence: Biotic degradation in air 2.3.a
Annex VIII
8.1.1 404 Skin Irritation  (based on in vivo) 4.4
8.2.1 405 Eye irritation (based on in vivo) 4.9
8.4.2 473 Mutagenicity - In vitro study in Mammalian Cells 4.10
8.5.2 403 Acute Inhalation Toxicity 4.1
8.8.1 417 Assessment of Toxicokinetic Behaviour: Blood-brain barrier partition / Human Serum Albumin Binding 5.4 / 5.9 /6.4
9.1.3 203 Acute Toxicity Test  - Fish 3.3
9.1.4 209 Toxicity to Activated Sludge 3.6
9.2.2 Persistence - Abiotic degradation in air 2.2.b
223 Acute Toxicity to Birds 3.12.a
9.3.1 121 Adsorption/Desorption Screening 2.6
Annex IX
8.6.2 408 Sub-chronic Toxicity study (90 day) repeated dose toxicity oral 4.14
8.7.2 414 Prenatal developmental toxicity study 4.14
9.1.5 211 Daphnia magna reproduction test 3.4
9.1.6.1 210 Fish Early-Life Stage toxicity test 3.5
9.2.1.2 309 Persistence: biotic degradation in water 2.3a
9.2.1.3 307 Persistence: biotic degradation in soil 2.3a
9.2.1.4 308 Persistence: biotic degradation in sediment 2.3a
9.3.2 305 Bioaccumulation in Aquatic Species (BAF and BCF) 2.4a
9.4.1 214 Short-term Toxicity to Invertebrates (Honey Bee)
Annex X
8.6.3 452 Chronic Toxicity LOAEL 4.14
8.9.1 451 Carcinogenicity 4.12


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